Introduction 7 2. Drug delivery systems 11 2.1 Therapeutic advantages 2.2 Drug bioavailability 2.3 Conventional drug formats 2.4 Drug delivery systems 3. Oral drug delivery systems 17 3.1 Coated systems 3.2 Matrix systems 3.3 Hydrophilic, swellable, gellable or erodible polymers 3.4 Polymer dissolution rate 3.5 Molecule diffusion and transport in polymer systems 3.6 Drug release rate from a polymer matrix 3.7 Conventional hydrophilic, swellable, gellable matrices 3.8 In-vitro dissolution test and in-vitro/in-vivo correlation 4. GEOMATRIX technology 31 4.1 Drug release control mechanisms 4.2 Active core plus barriers 4.3 Study of the action mechanisms of barriers 4.4 Modulation of the drug release profile by the GEOMATRIX system 4.5 Swellable, gellable barriers 4.6 Erodible barriers 4.7 Manufacturing 4.8 Materials used 4.9 Development, scale-up, quality control, production and certification Versatility of the modular GEOMATRIX system 55 5.1 Examples of GEOMATRIX systems for extended release of drugs at a constant rate 5.2 Drug delivery systems for the controlled release of partially soluble drugs 5.3 Drug delivery systems for the delayed release of drugs 5.4 Drug delivery systems for the bi-phasic release of drugs 5.5 Drug delivery systems for the release of two or more drugs at different rates (binary release) 5.6 Drug delivery systems for the pulsed release of drugs 6 Conclusions 81 7 References 85
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