Role of tumor cells contaminating the graft in breast cancer recurrence after high-dose chemotherapy

Pedrazzoli, P; Battaglia, M; Da Prada, G A; Lanza, A; Cuomo, A; Bertolini, F; Pavesi, L; Robustelli della Cuna, G

doi:10.1038/sj.bmt.1700854

One of the possible drawbacks to autologous stem cell transplantation in breast cancer (BC) patients is the potential for tumor contamination in the transplanted product. We present a patient with advanced disease who received high-dose chemotherapy (HDC) and PBPC support as consolidation therapy after achieving complete remission with standard-dose first-line treatment, and suffered recurrence of the disease 6 months after transplantation. Retrospective analysis revealed the presence of contaminating cells in the leukapheretic product, and clinical evidence suggested a role for these cells in the tumor relapse.

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Titolo:	Role of tumor cells contaminating the graft in breast cancer recurrence after high-dose chemotherapy
Autori:	PEDRAZZOLI, PAOLO Battaglia, M Da Prada, G A Lanza, A Cuomo, A Bertolini, F Pavesi, L Robustelli della Cuna, G mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1997
Rivista:	BONE MARROW TRANSPLANTATION
Abstract:	One of the possible drawbacks to autologous stem cell transplantation in breast cancer (BC) patients is the potential for tumor contamination in the transplanted product. We present a patient with advanced disease who received high-dose chemotherapy (HDC) and PBPC support as consolidation therapy after achieving complete remission with standard-dose first-line treatment, and suffered recurrence of the disease 6 months after transplantation. Retrospective analysis revealed the presence of contaminating cells in the leukapheretic product, and clinical evidence suggested a role for these cells in the tumor relapse.
Handle:	http://hdl.handle.net/11571/1234166
Appare nelle tipologie:	1.1 Articolo in rivista

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