Effects of anthocyanins on cell cycle progression in normal human fibroblasts

Anthocyanins are flavonoids and constitute the largest group of water–soluble pigment. It has been reported that anthocyanins exert several therapeutical activities, acting as anti-inflammatories, maintaining the normal vascular permeability, and exerting anticarcinogenic effects in vitro. The above effects have been related mainly to the antioxidant properties of anthocyanins, since they have been demonstrated to act as antioxidants both in vitro and in vivo. In this study, different anthocyanins namely delphinidin, (DP) cyanidin (CY), and their glycosilated and rutinosinated derivatives, i.e. delphinidin-3-glucoside, delphinidin-3-rutinoside, cyanidin-3-glucoside, and delphinidin-3-rutinoside, contained in blackcurrant, have been tested for their ability to influence cell cycle progression in normal human fibroblasts.