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We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Mura M.;Pisano F.;Ginevrino M.;Calabro F.;Crotti L.;Valente E. M.;Schwartz P. J.;Gnecchi M.
2019-01-01

Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).
2019
Cardiovascular & Hematology Research
Medical Research, General Topics covers a wide array of topics in medical and biomedical research, with a specific emphasis on human disease, human tissues, and all levels of research into the pathogenesis of clinically significant conditions. Specific medical fields that are characterized by the inclusion of material from several other specializations are also covered here; these include general and internal medicine, tropical medicine, pediatrics, gerontology, epidemiology, and public health. Resources dealing with specific clinical interventions are excluded and are placed in the Medical Research: Diagnosis & Treatment category. Resources that emphasize the specific disease types, or specific systems affected are also excluded and are categorized according to the pathogen or system pathophysiology.
Molecular Biology & Genetics
STEM CELL RESEARCH
sì
WOS:000472548200010
2-s2.0-85063950564
Esperti anonimi
Inglese
Internazionale
STAMPA
37
101431
30974404
http://www.elsevier.com/wps/find/journaldescription.cws_home/711630/description#description
sì
11
info:eu-repo/semantics/article
262
Mura, M.; Lee, Y. -K.; Pisano, F.; Ginevrino, M.; Boni, M.; Calabro, F.; Crotti, L.; Valente, E. M.; Schwartz, P. J.; Tse, H. -F.; Gnecchi, M....espandi
1 Contributo su Rivista::1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1273528
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