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In this issue of Blood, Lee et al identify huntingtin associated protein 1 (HAP1) loss as a new marker of L-asparaginase resistance in acute lymphoblastic leukemia (ALL) and provide evidence for the pathway involved. They discovered that HAP1 is essential for the formation of the ternary complex with huntingtin (Htt) and inositol 1,4,5-triphosphate receptor (InsP3R) and that its loss impairs the L-asparaginase– mediated increase of cytosolic Ca21 needed for triggering apoptosis (see figure). Their data were confirmed by specific knockdown of HAP1 in SEM cells and by measurement of both endoplasmic reticulum–released Ca21 and external Ca21 influx.1

HAP1 loss in L-asparaginase resistance

Maggi M.
Writing – Review & Editing
;Scotti C.
Writing – Review & Editing
2019-01-01

Abstract

In this issue of Blood, Lee et al identify huntingtin associated protein 1 (HAP1) loss as a new marker of L-asparaginase resistance in acute lymphoblastic leukemia (ALL) and provide evidence for the pathway involved. They discovered that HAP1 is essential for the formation of the ternary complex with huntingtin (Htt) and inositol 1,4,5-triphosphate receptor (InsP3R) and that its loss impairs the L-asparaginase– mediated increase of cytosolic Ca21 needed for triggering apoptosis (see figure). Their data were confirmed by specific knockdown of HAP1 in SEM cells and by measurement of both endoplasmic reticulum–released Ca21 and external Ca21 influx.1
2019
Medical Research, General Topics covers a wide array of topics in medical and biomedical research, with a specific emphasis on human disease, human tissues, and all levels of research into the pathogenesis of clinically significant conditions. Specific medical fields that are characterized by the inclusion of material from several other specializations are also covered here; these include general and internal medicine, tropical medicine, pediatrics, gerontology, epidemiology, and public health. Resources dealing with specific clinical interventions are excluded and are placed in the Medical Research: Diagnosis & Treatment category. Resources that emphasize the specific disease types, or specific systems affected are also excluded and are categorized according to the pathogen or system pathophysiology.
BLOOD
sì
WOS:000468100200004
2-s2.0-85066851483
Comitato scientifico
Inglese
Internazionale
STAMPA
133
20
2116
2118
3
31097534
HAP-1, asparaginase
http://www.bloodjournal.org/content/bloodjournal/133/20/2116.full.pdf
no
2
info:eu-repo/semantics/article
262
Maggi, M.; Scotti, C.
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1278867
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