Blood platelets and resident neurons are fundamentally different cells, with peculiar features in embryological origin, function, and localization. However, they share common characteristics in subcellular organization and in protein composition.1 One of the most intriguing observations is that several proteins are typically expressed in both neurons and circulating platelets. In the latter, their concentrations are unusually high, and they are found to regulate processes such as platelet activation, hemostasis, and thrombosis.
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