5-Hydroxy-isoxazolidinic heterocycles can be easily prepared from hydroxamic acids and suitable ,- unsaturated aldehydes or ketones in good yields from solid state synthesis, selectively promoted by DEAE-C. The synthesized products were efficiently derivatized with representative heterobases for the preparation of nucleoside analogues suitable for biological evaluation and SAR analysis.
DEAE-cellulose-catalyzed synthesis of 5-hydroxy-isoxazolidines and their synthetic uses towards nucleoside analogues
Quadrelli, Paolo
Writing – Original Draft Preparation
2020-01-01
Abstract
5-Hydroxy-isoxazolidinic heterocycles can be easily prepared from hydroxamic acids and suitable ,- unsaturated aldehydes or ketones in good yields from solid state synthesis, selectively promoted by DEAE-C. The synthesized products were efficiently derivatized with representative heterobases for the preparation of nucleoside analogues suitable for biological evaluation and SAR analysis.File in questo prodotto:
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