IRIS

A major controversy regarding dialysis related amyloidosis (DRA) is about the presence and the role of truncated forms of beta2-microglobulin (beta2M) in the amyloid fibrils. Whereas Linke et al have reported the presence of proteolyzed forms of beta2M in the amyloid deposits in over 12 cases, other groups have not confirmed this finding. A similar analysis conduced in our laboratory with beta2-fibrils obtained from six patients confirms Linke's data.

DETECTION OF FRAGMENTS OF BETA2-MICROGLOBULIN IN AMYLOID FIBRILS

STOPPINI, MONICA;ARCIDIACO, PATRIZIA;MANGIONE, PALMA;GIORGETTI, SOFIA;BELLOTTI, VITTORIO
2000-01-01

Abstract

A major controversy regarding dialysis related amyloidosis (DRA) is about the presence and the role of truncated forms of beta2-microglobulin (beta2M) in the amyloid fibrils. Whereas Linke et al have reported the presence of proteolyzed forms of beta2M in the amyloid deposits in over 12 cases, other groups have not confirmed this finding. A similar analysis conduced in our laboratory with beta2-fibrils obtained from six patients confirms Linke's data.
2000
Biochemistry & Biophysics focuses on the structure and chemistry of biomolecules and covers all aspects of basic biochemistry/biophysics, including molecular structure, enzyme kinetics and protein-protein interaction; this category also contains cross-disciplinary resources focused on a specific class of biological molecules, e.g., nucleic acids, steroids, magnesium, growth factors, free radicals, bio-membranes, and peptides. Excluded are resources dealing with the application of biochemical techniques to specific topics listed elsewhere in CC/LS. Resources with a strong emphasis on the integration of biochemical pathways (such as signal transduction or molecular motors) at the cellular level are placed in the Cell & Developmental Biology category.
KIDNEY INTERNATIONAL
sì
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
57
349
350
beta2-microglobulin; amyloid fibrils
6
info:eu-repo/semantics/article
262
Stoppini, Monica; Arcidiaco, Patrizia; Mangione, Palma; Giorgetti, Sofia; Brancaccio, D.; Bellotti, Vittorio
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/133756
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact