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Allergic sensitization is mediated by immunoglobulin E (IgE) and an increase of their total value is frequently used to complete a correct diagnosis of atopy. Serum IgE may be considered a typical biomarker for the allergic phenotype. The aim of this study was to evaluate total serum IgE, according to sensitizations and to find a cut off to discriminate between atopic and non-atopic subjects. Seven hundred and ninety-five patients were enrolled in this study. Serum levels of total IgE were measured by a fluorescence immunoassay (ImmunoCAP; ThermoFisher, Uppsala, Sweden) while specific IgE levels were measured by immunofluorometric assay (ImmunoCAP; ThermoFisher, Uppsala, Sweden). Both tests were expressed in kU/L, according to manufacturer’s instructions.

SERUM IMMUNOGLOBULIN IgE IN A PEDIATRIC POPULATION: A RETROSPECTIVE ANALYSIS

DE AMICI, MARA;MARSEGLIA, ALESSIA;LICARI, AMELIA;Caimmi, S;MARSEGLIA, GIAN LUIGI
2015-01-01

Abstract

Allergic sensitization is mediated by immunoglobulin E (IgE) and an increase of their total value is frequently used to complete a correct diagnosis of atopy. Serum IgE may be considered a typical biomarker for the allergic phenotype. The aim of this study was to evaluate total serum IgE, according to sensitizations and to find a cut off to discriminate between atopic and non-atopic subjects. Seven hundred and ninety-five patients were enrolled in this study. Serum levels of total IgE were measured by a fluorescence immunoassay (ImmunoCAP; ThermoFisher, Uppsala, Sweden) while specific IgE levels were measured by immunofluorometric assay (ImmunoCAP; ThermoFisher, Uppsala, Sweden). Both tests were expressed in kU/L, according to manufacturer’s instructions.
2015
Immunology incorporates cellular and molecular studies in immunology, as well as clinical research in immunopathology, infectious disease, autoimmunity, and allergy. Host-pathogen interactions in infectious disease, as well as experimental therapeutic applications of immunomodulating agents are also considered. Resources dealing primarily with the biology of microbial, viral, or parasitic pathogens are excluded and are covered in the Microbiology category.
Medical Research, General Topics covers a wide array of topics in medical and biomedical research, with a specific emphasis on human disease, human tissues, and all levels of research into the pathogenesis of clinically significant conditions. Specific medical fields that are characterized by the inclusion of material from several other specializations are also covered here; these include general and internal medicine, tropical medicine, pediatrics, gerontology, epidemiology, and public health. Resources dealing with specific clinical interventions are excluded and are placed in the Medical Research: Diagnosis & Treatment category. Resources that emphasize the specific disease types, or specific systems affected are also excluded and are categorized according to the pathogen or system pathophysiology.
JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
2-s2.0-84986220622
Esperti anonimi
Inglese
Internazionale
ELETTRONICO
29
2 Suppl 1
64
69
6
26638698
total IgE, specific IgE, sensitization
no
8
info:eu-repo/semantics/article
262
DE AMICI, Mara; Marseglia, Alessia; Licari, Amelia; Caimmi, S; Nigrisoli, S; Torre, C; Testa, G; Marseglia, GIAN LUIGI
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1344516
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