The berberine bridge enzyme catalyses the crucial step in the biosynthesis of an important class of alkaloids through a reaction that cannot be carried out using conventional organic chemistry tools. Characterization of the enzyme demonstrates a concerted mechanism which couples two distinct chemical steps – oxidation and proton abstraction - affecting two separate groups of the substrate.
Cyclization in concert.
MATTEVI, ANDREA
2008-01-01
Abstract
The berberine bridge enzyme catalyses the crucial step in the biosynthesis of an important class of alkaloids through a reaction that cannot be carried out using conventional organic chemistry tools. Characterization of the enzyme demonstrates a concerted mechanism which couples two distinct chemical steps – oxidation and proton abstraction - affecting two separate groups of the substrate.File in questo prodotto:
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