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In a previous work, we demonstrated that the Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. In this study, the orthologous genes from Mycobacterium smegmatis mc2155 were inactivated and mutants analyzed. Rv2358 protein was purified and found to bind upstream of the Rv2358 gene. Binding was inhibited by Zn2+ ions.

Rv2358-FurB: two transcriptional regulators from Mycobacterium tuberculosis which respond to zinc

CANNEVA, FABIO;BRANZONI, MANUELA;RICCARDI, GIOVANNA;MILANO, ANNA
2005-01-01

Abstract

In a previous work, we demonstrated that the Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. In this study, the orthologous genes from Mycobacterium smegmatis mc2155 were inactivated and mutants analyzed. Rv2358 protein was purified and found to bind upstream of the Rv2358 gene. Binding was inhibited by Zn2+ ions.
2005
Microbiology covers the biology and biochemistry of microorganisms, bacterial, viral, and parasitic, as well as the medical implications and treatments of the subset of these organisms known to cause disease in humans and/or animals. Biotechnology applications of microorganisms for basic science or clinical use are also covered. Resources that emphasize immune response to pathogens and its modulation by clinical intervention are excluded and are covered in the Immunology category.
JOURNAL OF BACTERIOLOGY
sì
000231026200038
2-s2.0-23644435460
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
187
16
5837
5840
16077132
Tematica Ex SIR: Studio di regolatori coinvolti nello stress da metalli in Mycobacterium smegmatis e M. tuberculosis (Classif. Ex SIR:Articoli su riviste ISI )
Mycobacterium tuberculosis; Zinc; Transcriptional Regulators
5
info:eu-repo/semantics/article
262
Canneva, Fabio; Branzoni, Manuela; Riccardi, Giovanna; Provvedi, R.; Milano, Anna
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/134655
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