The prevalence, heterogeneity, and severity of type 2 inflammatory diseases, includ- ing asthma and atopic dermatitis, continue to rise, especially in children and adoles- cents. Type 2 inflammation is mediated by both innate and adaptive immune cells and sustained by a specific subset of cytokines, such as interleukin (IL)-4, IL-5,IL-13, and IgE. IL-4 and IL-13 are considered signature type 2 cytokines, as they both have a pivotal role in many of the pathobiologic changes featured in asthma and atopic dermatitis. Several biologics targeting IL-4, IL-5, and IL-13, as well as IgE, have been proposed to treat severe allergic disease in the pediatric population with promising results. A better definition of type 2 inflammatory pathways is essential to implement targeted therapeutic strategies.

Type-2 inflammatory mediators as targets for precision medicine in children

Castagnoli, Riccardo;Licari, Amelia
;
Marseglia, Gian Luigi
2020

Abstract

The prevalence, heterogeneity, and severity of type 2 inflammatory diseases, includ- ing asthma and atopic dermatitis, continue to rise, especially in children and adoles- cents. Type 2 inflammation is mediated by both innate and adaptive immune cells and sustained by a specific subset of cytokines, such as interleukin (IL)-4, IL-5,IL-13, and IgE. IL-4 and IL-13 are considered signature type 2 cytokines, as they both have a pivotal role in many of the pathobiologic changes featured in asthma and atopic dermatitis. Several biologics targeting IL-4, IL-5, and IL-13, as well as IgE, have been proposed to treat severe allergic disease in the pediatric population with promising results. A better definition of type 2 inflammatory pathways is essential to implement targeted therapeutic strategies.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11571/1350904
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