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We analyzed the effects of seletracetam (ucb 44212; SEL), a new antiepileptic drug candidate, in an in vitro model of epileptic activity. The activity of SEL was compared to the effects of levetiracetam (LEV; Keppra), in the same assays.

Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro

PISANI, ANTONIO
2009-01-01

Abstract

We analyzed the effects of seletracetam (ucb 44212; SEL), a new antiepileptic drug candidate, in an in vitro model of epileptic activity. The activity of SEL was compared to the effects of levetiracetam (LEV; Keppra), in the same assays.
2009
EPILEPSIA
sì
WOS:000264821700012
2-s2.0-64049087839
Esperti anonimi
Inglese
Internazionale
STAMPA
50
4
702
710
9
19055493
Animals; Calcium; Dose-Response Relationship; Drug; Pyrrolidinones; Bicuculline; Calcium Channel Blockers; Neural Inhibition; Biophysics; Rats; Calcium Channels; GABA Antagonists; Patch-Clamp Techniques; Neurons; Rats; Wistar; Potassium Channel Blockers; Piracetam; Membrane Potentials; 4-Aminopyridine; Magnesium; Neocortex; Anticonvulsants; Male
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2008.01915.x
no
8
info:eu-repo/semantics/article
262
Martella, Giuseppina; Bonsi, P; Sciamanna, Giuseppe; Platania, P; Madeo, Graziella; Tassone, A; Cuomo, D; Pisani, Antonio
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1352458
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