Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders.Their site andmechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression ofH1andH3 histamine receptors in the frog and mouse semicircular canal sensory epithelia. Analysis was performed by mRNA reverse transcriptase-PCR, immunoblotting and immunocytochemistry experiments. Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found.
Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia.
BOTTA, LAURA;TRITTO, SIMONA;PERIN, PAOLA;LAFORENZA, UMBERTO;GASTALDI, GIULIA;ZAMPINI, VALERIA;ZUCCA, GIANPIERO;MASETTO, SERGIO;VALLI, PAOLO
2008-01-01
Abstract
Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders.Their site andmechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression ofH1andH3 histamine receptors in the frog and mouse semicircular canal sensory epithelia. Analysis was performed by mRNA reverse transcriptase-PCR, immunoblotting and immunocytochemistry experiments. Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
