L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons

Pisani, A; Calabresi, P; Tozzi, A; D'Angelo, V; Bernardi, G

doi:10.1161/01.str.29.1.196

Experimental evidence supports a major role of increased intracellular calcium [Ca2+]i levels in the induction of neuronal damage during cerebral ischemia. However, the source of Ca2+ rise has not been fully elucidated. To clarify further the role and the origin of Ca2+ in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro model of oxygen (O2)/glucose deprivation.

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Titolo:	L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons
Autori:	PISANI, ANTONIO Calabresi P Tozzi A D'Angelo V Bernardi G mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1998
Rivista:	STROKE
Abstract:	Experimental evidence supports a major role of increased intracellular calcium [Ca2+]i levels in the induction of neuronal damage during cerebral ischemia. However, the source of Ca2+ rise has not been fully elucidated. To clarify further the role and the origin of Ca2+ in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro model of oxygen (O2)/glucose deprivation.
Handle:	http://hdl.handle.net/11571/1352975
Appare nelle tipologie:	1.1 Articolo in rivista

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