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Are laboratory tests useful for monitoring the activity of lupus nephritis? A six year prospective study in a cohort of 228 lupus nephritis patients.

QUAGLINI, SILVANA;
2009-01-01
2009
Medical Research, Diagnosis & Treatment contains studies of existing and developing diagnostic and therapeutic techniques, as well as specific classes of clinical intervention. Resources in this category emphasize the difference between normal and disease states, with the ultimate goal of more effective diagnosis and intervention. Specific areas of interest include pathology and histochemical analysis of tissue, clinical chemistry and biochemical analysis of medical samples, diagnostic imaging, radiology and radiation, surgical research, anesthesiology and anesthesia, transplantation, artificial tissues, and medical implants. Resources focused on the disease, diagnosis, and treatment of specific organs or physiological systems are excluded and are covered in the Medical Research: Organs & Systems category.
ANNALS OF THE RHEUMATIC DISEASES
sì
WOS:000262394000014
2-s2.0-58849111801
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
68
2
234
237
4
18718989
OBJECTIVES: To evaluate the role of immunological tests for monitoring lupus nephritis (LN) activity. METHODS: C3, C4, anti-dsDNA and anti-C1q antibodies were prospectively performed over 6 years in 228 LN patients. RESULTS: In membranous LN only anti-C1q antibodies differentiated proteinuric flares from quiescent disease (p=0.02). However, in this group 46\% of flares occurred with a normal value of anti-C1q antibodies versus 20\% in proliferative LN (p=0.02). In patients with antiphospholipid antibodies (APL), 33\% of flares occurred with normal levels of anti-C1q antibodies versus 14.5\% in APL-negative patients (p=0.02). In proliferative LN, anti-C1q antibodies showed a slightly better sensitivity and specificity (80.5 and 71\% respectively) than other tests for the diagnosis of renal flares. All 4 tests had good negative predictive value (NPV). At univariate analysis anti-C1q was the best renal flare predictor (p<0.0005). At multivariate analysis, the association of anti-C1q with C3 and C4 provided the best performance (p<0.0005,p<0.005,p<0.005 respectively). CONCLUSIONS: Anti-C1q is slightly better than the other tests to confirm the clinical activity of LN, particularly in patients with proliferative LN and in the absence of APL. All 4 "specific" tests had a good NPV, suggesting that, in the presence of normal values of each, active LN is unlikely.
lupus nephritis; statistical analysis; prospective study
9
info:eu-repo/semantics/article
262
Gabriella, Moroni; Antonella, Radice; Gaia, Giammarresi; Quaglini, Silvana; Beniamina, Gallelli; Antonio, Leoni; Maurizio Li, Vecchi; Piergiorgio, Mes...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/135363
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