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Serum IL-4 as a marker of immunological response to sublingual immunotherapy.

QUAGLINI, SILVANA;MARSEGLIA, GIAN LUIGI;DE AMICI, MARA
2008-01-01
2008
Medical Research, Diagnosis & Treatment contains studies of existing and developing diagnostic and therapeutic techniques, as well as specific classes of clinical intervention. Resources in this category emphasize the difference between normal and disease states, with the ultimate goal of more effective diagnosis and intervention. Specific areas of interest include pathology and histochemical analysis of tissue, clinical chemistry and biochemical analysis of medical samples, diagnostic imaging, radiology and radiation, surgical research, anesthesiology and anesthesia, transplantation, artificial tissues, and medical implants. Resources focused on the disease, diagnosis, and treatment of specific organs or physiological systems are excluded and are covered in the Medical Research: Organs & Systems category.
JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
sì
WOS:000257959500005
2-s2.0-48749098153
Esperti anonimi
Inglese
Internazionale
STAMPA
22
2
117
123
6
18597704
Allergic rhinitis (AR) is characterized by a Th2 polarized immune response. Specific Immunotherapy modifies this bias restoring a physiologic Th1 profile. Sublingual immunotherapy (SLIT) is widely prescribed, but there is no early, simple marker of response. This study was undertaken in order to determine whether serum IL-4 might be a possible marker of SLIT immunological response in order to quickly and easily detect responder patients. Thirty-nine AR patients with a pollen allergy assumed preseasonal SLIT for 3 months. VAS for symptoms and medication efficacy were evaluated. Serum IL-4 was assessed before and 3 and 6 months after SLIT initiation. Eighty-two percent of patients (32/39) showed a clinical response to SLIT. Serum IL-4 significantly decreased at 6 months post-therapy in responders, whereas it increased in non-responders. In conclusion, these results may be considered clinically relevant proof that SLIT treatment induces a quick reduction in Th2 polarization. Serum IL-4 appears to be an early marker of immunological response to SLIT.
statistical analysis; allergy; diagnostic system
8
info:eu-repo/semantics/article
262
G., Ciprandi; M., De Amici; G., Murdaca; B. M., Colombo; Quaglini, Silvana; Marseglia, GIAN LUIGI; M., Di Gioacchino; DE AMICI, Mara
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/135365
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