Sciamanna et al. show overt alterations in neuronal excitability of the globus pallidus in a dystonia mouse model. Pallidal neurons show impairments in firing rate and pattern, caused by altered dopamine D2 receptor control over GABAergic striatopallidal synapses with subsequent downregulation of HCN channels.
Optogenetic Activation of Striatopallidal Neurons Reveals Altered HCN Gating in DYT1 Dystonia
Pisani A.
2020-01-01
Abstract
Sciamanna et al. show overt alterations in neuronal excitability of the globus pallidus in a dystonia mouse model. Pallidal neurons show impairments in firing rate and pattern, caused by altered dopamine D2 receptor control over GABAergic striatopallidal synapses with subsequent downregulation of HCN channels.File in questo prodotto:
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