A theoretical model and a Monte Carlo code for chromosome aberration (CA) induction are presented. The model, which can provide dose-response curves for different simple and complex aberration types, is based on the assumption that clustered DNA damage plays a key role in CA induction and that only lesions in the same chromosome territory or in neighbouring territories can interact and give raise to aberrations. Interphase chromosome localisation was taken into account by describing chromosome territories as compact domains with volume proportional to the DNA content. The model predictions showed very good agreement with data relative to different aberrations induced by gamma rays, protons and alpha particles. This provided a validation of the model, which can be used for the interpretation of available data and for the estimation of cancer risk after space radiation exposure, since chromosome aberrations are positively correlated with cancer induction. Indeed the simulation of mixed fields is already possible and the implementation of ions heavier than alpha particles is a priority for the future developments of this work.
Modelling Radiation-Induced Chromosome Aberrations For Space Risk Assessment
BALLARINI, FRANCESCA;OTTOLENGHI, ANDREA DAVIDE
2002-01-01
Abstract
A theoretical model and a Monte Carlo code for chromosome aberration (CA) induction are presented. The model, which can provide dose-response curves for different simple and complex aberration types, is based on the assumption that clustered DNA damage plays a key role in CA induction and that only lesions in the same chromosome territory or in neighbouring territories can interact and give raise to aberrations. Interphase chromosome localisation was taken into account by describing chromosome territories as compact domains with volume proportional to the DNA content. The model predictions showed very good agreement with data relative to different aberrations induced by gamma rays, protons and alpha particles. This provided a validation of the model, which can be used for the interpretation of available data and for the estimation of cancer risk after space radiation exposure, since chromosome aberrations are positively correlated with cancer induction. Indeed the simulation of mixed fields is already possible and the implementation of ions heavier than alpha particles is a priority for the future developments of this work.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
