We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong well-posedness of the system in a general framework through monotonicity and stochastic compactness arguments. We introduce then suitable controls representing the concentration of cytotoxic drugs administered in medical treatment and we analyze a related optimal control problem. We derive existence of an optimal strategy and deduce first-order necessary optimality conditions by studying the corresponding linearized system and the backward adjoint system.

Optimal control of stochastic phase-field models related to tumor growth

Orrieri, Carlo;Rocca, Elisabetta;Scarpa, Luca
2020-01-01

Abstract

We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong well-posedness of the system in a general framework through monotonicity and stochastic compactness arguments. We introduce then suitable controls representing the concentration of cytotoxic drugs administered in medical treatment and we analyze a related optimal control problem. We derive existence of an optimal strategy and deduce first-order necessary optimality conditions by studying the corresponding linearized system and the backward adjoint system.
2020
The Mathematics category includes resources dealing with mathematics, applied mathematics, statistics and probability.
Esperti anonimi
Inglese
Internazionale
26
104
46
Stochastic systems of partial differential equations / Cahn-Hilliard equation / optimal control, first-order necessary conditions / tumor growth
https://www.esaim-cocv.org/articles/cocv/abs/2020/01/cocv190130/cocv190130.html
3
info:eu-repo/semantics/article
262
Orrieri, Carlo; Rocca, Elisabetta; Scarpa, Luca
1 Contributo su Rivista::1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1361134
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