The alkylation reaction of 9-methyladenine and 9-methylguanine (as prototype substrates of deoxyadenosine and -guanosine), by the parent o-quinone methide (o-QM), has been investigated in the gas phase and in aqueous solution, using density functional theory at the B3LYP/6-311+G(d,p) level.

Selectivity of Purine Alkylation by a Quinone Methide. Kinetic or Thermodynamic Control?

FRECCERO, MAURO
;
GANDOLFI, REMO;
2003-01-01

Abstract

The alkylation reaction of 9-methyladenine and 9-methylguanine (as prototype substrates of deoxyadenosine and -guanosine), by the parent o-quinone methide (o-QM), has been investigated in the gas phase and in aqueous solution, using density functional theory at the B3LYP/6-311+G(d,p) level.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/136341
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