On 16 November 2011, the US Food and Drug Administration (FDA) approved ruxolitinib, a small-molecule inhibitor of JAK1/2, for the treatment of patients with intermediate- or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis. In this issue of Blood, Porpaczy et al report findings of a study showing that JAK1/2 inhibitor treatment is associated with an increased risk for aggressive B-cell lymphomas.

Benefits and risks of JAK inhibition

Arcaini L.;Cazzola M.
2018

Abstract

On 16 November 2011, the US Food and Drug Administration (FDA) approved ruxolitinib, a small-molecule inhibitor of JAK1/2, for the treatment of patients with intermediate- or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis. In this issue of Blood, Porpaczy et al report findings of a study showing that JAK1/2 inhibitor treatment is associated with an increased risk for aggressive B-cell lymphomas.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1363417
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 6
social impact