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The present invention relates to a screening method for the identification of new nitrobenzothiazinone drugs for the treatment of tuberculosis, which are not or are slowly transformed and inactivated by nitroreductase. The use of the nitroreductase NfnB from M. smegmatis in cancer therapy, and in bioremediation are comprised as well.

NITROREDUCTASE NfnB FROM Mycobacterium smegmatis

RICCARDI, GIOVANNA;MANINA, GIULIA;PASCA, MARIA ROSALIA
2008-01-01

Abstract

The present invention relates to a screening method for the identification of new nitrobenzothiazinone drugs for the treatment of tuberculosis, which are not or are slowly transformed and inactivated by nitroreductase. The use of the nitroreductase NfnB from M. smegmatis in cancer therapy, and in bioremediation are comprised as well.
2008
Microbiology covers the biology and biochemistry of microorganisms, bacterial, viral, and parasitic, as well as the medical implications and treatments of the subset of these organisms known to cause disease in humans and/or animals. Biotechnology applications of microorganisms for basic science or clinical use are also covered. Resources that emphasize immune response to pathogens and its modulation by clinical intervention are excluded and are covered in the Immunology category.
PCT/EP2008/009231
UNIVERSITA' DEGLI STUDI DI PAVIA
Tuberculosis; Nitroreductase; benzothiazinones; drug resistance
6 Brevetti::6.1 Brevetto
none
Riccardi, Giovanna; Manina, Giulia; Pasca, MARIA ROSALIA
info:eu-repo/semantics/patent
285
3
6.1 Brevetto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/136429
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