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Yields of double-strand breaks and frequency distributions of DNA fragment lengths after ion irradiation were calculated using different assumptions on the DNA target model. The influence of assumptions on particular geometric chromosome models on calculated chromosome aberration data is illustrated with two target-modelling approaches for this end point.

First steps towards systems radiation biology studies concernedwith DNA and chromosome structure within living cells

BALLARINI, FRANCESCA;OTTOLENGHI, ANDREA DAVIDE;
2008-01-01

Abstract

Yields of double-strand breaks and frequency distributions of DNA fragment lengths after ion irradiation were calculated using different assumptions on the DNA target model. The influence of assumptions on particular geometric chromosome models on calculated chromosome aberration data is illustrated with two target-modelling approaches for this end point.
2008
Biochemistry & Biophysics focuses on the structure and chemistry of biomolecules and covers all aspects of basic biochemistry/biophysics, including molecular structure, enzyme kinetics and protein-protein interaction; this category also contains cross-disciplinary resources focused on a specific class of biological molecules, e.g., nucleic acids, steroids, magnesium, growth factors, free radicals, bio-membranes, and peptides. Excluded are resources dealing with the application of biochemical techniques to specific topics listed elsewhere in CC/LS. Resources with a strong emphasis on the integration of biochemical pathways (such as signal transduction or molecular motors) at the cellular level are placed in the Cell & Developmental Biology category.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
sì
WOS:000252875700007
2-s2.0-39049115468
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
47
1
49
61
SYSTEMS BIOLOGY; DNA DAMAGE; CHROMOSOME ABERRATIONS; MONTE CARLO SIMULATIONS
6
info:eu-repo/semantics/article
262
Werner, Friedland; Herwig, Paretzke; Ballarini, Francesca; Ottolenghi, ANDREA DAVIDE; Gregor, Kreth; Cristoph, Cremer
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/137421
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