The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease

Picillo, M.; Palladino, R.; Erro, R.; Alfano, R.; Colosimo, C.; Marconi, R.; Antonini, A.; Barone, P.; Morgante, L.; Benincasa, D.; Quatrale, R.; Biguzzi, S.; Braga, M.; Ceravolo, G.; Capecci, M.; Meco, G.; Caravona, N.; Scala, R.; De Falco, F. A.; Pezzoli, G.; De Gaspari, D.; Bottacchi, E.; Di Giovanni, M.; Cannas, A.; Floris, G.; Gallerini, S.; Grasso, L.; Gaglio, R. M.; Gurgone, G.; Volpe, G.; Zappulla, S.; Ceravolo, R.; Kiferle, L.; Ramat, S.; Meoni, S.; Pisani, A.; Moschella, V.; Morgante, F.; Savica, R.; Pepe, F.; Ciccarelli, G.; Petretta, V.; Giglia, R. M.; Randisi, M. G.; Iemolo, F.; Avarello, T. P.; Romeno, M.; Santangelo, G.; Stocchi, F.; Sciortino, G.; Sorbello, V.; Nicoletti, A.; Tiple, D.; Fabbrini, G.; Bentivoglio, A.; Pontieri, F. E.; Guidubaldi, A.; Muoio, R.; Toni, V.; Del Dotto, P.; Logi, C.; Ciacci, G.; Ulivelli, M.; Perini, M.; Lanfranchi, S.; Griffini, S.; Troianiello, B.; Baratti, M.; Amidei, S.; Consoli, D.; Iellamo, M.; Cuomo, T.; Scaglioni, A.; Medici, D.; Manfredi, M.; Abbruzzese, G.; Di Brigida, G.; Cocco, G. A.; Agnetti, V.; Cossu, G.; Deriu, M.; Abrignani, M.; Modica, C.; Albani, G.; Milan, E.; Martinelli, P.; Scaglione, C.; Mucchiut, M.; Zanini, S.; Pennisi, F.; Soliveri, P.; Albanese, A.; Massimo, P.; Bartolomei, L.; Capus, L.; Ferigo, L.; Marano, R.; Nastasi, V.; Luciano, R.; Maiello, L.; Simone, P.; Fogli, D.; Lopiano, L.; Pesare, M.; Nordera, G.; Pilleri, E.; Scaravilli, T.; Giaccaglini, E.; Alesi, C.; Petrone, A.; Trianni, G.

doi:10.1007/s00415-020-10156-3

Objectives: To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods: A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results: As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions: Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.

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Titolo:	The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease
Autori:	Picillo M. Palladino R. Erro R. Alfano R. Colosimo C. Marconi R. Antonini A. Barone P. Morgante L. Benincasa D. Quatrale R. Biguzzi S. Braga M. Ceravolo G. Capecci M. Meco G. Caravona N. Scala R. De Falco F. A. Pezzoli G. De Gaspari D. Bottacchi E. Di Giovanni M. Cannas A. Floris G. Gallerini S. Grasso L. Gaglio R. M. Gurgone G. Volpe G. Zappulla S. Ceravolo R. Kiferle L. Ramat S. Meoni S. PISANI, ANTONIO Moschella V. Morgante F. Savica R. Pepe F. Ciccarelli G. Petretta V. Giglia R. M. Randisi M. G. Iemolo F. Avarello T. P. Romeno M. Santangelo G. Stocchi F. Sciortino G. Sorbello V. Nicoletti A. Tiple D. Fabbrini G. Bentivoglio A. Pontieri F. E. Guidubaldi A. Muoio R. Toni V. Del Dotto P. Logi C. Ciacci G. Ulivelli M. Perini M. Lanfranchi S. Griffini S. Troianiello B. Baratti M. Amidei S. Consoli D. Iellamo M. Cuomo T. Scaglioni A. Medici D. Manfredi M. Abbruzzese G. Di Brigida G. Cocco G. A. Agnetti V. Cossu G. Deriu M. Abrignani M. Modica C. Albani G. Milan E. Martinelli P. Scaglione C. Mucchiut M. Zanini S. Pennisi F. Soliveri P. Albanese A. Massimo P. Bartolomei L. Capus L. Ferigo L. Marano R. Nastasi V. Luciano R. Maiello L. Simone P. Fogli D. Lopiano L. Pesare M. Nordera G. Pilleri E. Scaravilli T. Giaccaglini E. Alesi C. Petrone A. Trianni G. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2020
Rivista:	JOURNAL OF NEUROLOGY
Abstract:	Objectives: To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods: A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results: As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions: Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.
Handle:	http://hdl.handle.net/11571/1378976
Appare nelle tipologie:	1.1 Articolo in rivista

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