The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [3H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.

mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors.

DE ROSSI, EDDA;BRANZONI, MANUELA;CANTONI, RITA MARIA;MILANO, ANNA;RICCARDI, GIOVANNA;CIFERRI, ORIO
1998-01-01

Abstract

The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [3H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/138048
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