Due to the reduction of the ozone layer, there is an increasing need of effective UV protection systems with minimised side-effects. Octylmethoxycinnamate (OMC) represents one of the most widely used sunscreen compound. Several studies demonstrated that OMC is unstable following UV irradiation both in solution and in emulsion formulations. In order to ensure adequate efficacy and safety for this sunscreen agent, there is a need for new carrier systems to enhance OMC photostability. In the present study nanoparticles based on poly-D,L-lactide (PLA) as carrier for OMC were investigated. Photostability results show a significant reduction in photoisomerization degree when sunscreen is loaded in nanoparticles, highlighting that the encapsulation is a suitable strategy to improve OMC photostability. Moreover sun protection factor (SPF) results show that the UVB filter protective power is mantained also after encapsulation.
Nanoencapsulation may improve sunscreen agents
VETTOR, MANUELA TERESA;PERUGINI, PAOLA;PAVANETTO, FRANCA
2008-01-01
Abstract
Due to the reduction of the ozone layer, there is an increasing need of effective UV protection systems with minimised side-effects. Octylmethoxycinnamate (OMC) represents one of the most widely used sunscreen compound. Several studies demonstrated that OMC is unstable following UV irradiation both in solution and in emulsion formulations. In order to ensure adequate efficacy and safety for this sunscreen agent, there is a need for new carrier systems to enhance OMC photostability. In the present study nanoparticles based on poly-D,L-lactide (PLA) as carrier for OMC were investigated. Photostability results show a significant reduction in photoisomerization degree when sunscreen is loaded in nanoparticles, highlighting that the encapsulation is a suitable strategy to improve OMC photostability. Moreover sun protection factor (SPF) results show that the UVB filter protective power is mantained also after encapsulation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
