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We studied a patient with hypereosinophilic syndrome (HES) who had myeloproliferative features, was unresponsive to imatinib mesylate, and showed cyclic oscillations in blood cell counts. No rearrangement in PDGFRA, PDGFRB and ETV6 genes was detected. Clonal analysis of hematopoiesis consistently showed skewed X-chromosome inactivation patterns in both granulocytes and T-lymphocytes, indicating a clonal myeloproliferative disorder originating in a pluripotent stem cell.

Hypereosinophilic syndrome and cyclic oscillations in blood cell counts. A clonal disorder of hematopoiesis originating in a pluripotent stem cell.

MALCOVATI, LUCA;CAZZOLA, MARIO
2004-01-01

Abstract

We studied a patient with hypereosinophilic syndrome (HES) who had myeloproliferative features, was unresponsive to imatinib mesylate, and showed cyclic oscillations in blood cell counts. No rearrangement in PDGFRA, PDGFRB and ETV6 genes was detected. Clonal analysis of hematopoiesis consistently showed skewed X-chromosome inactivation patterns in both granulocytes and T-lymphocytes, indicating a clonal myeloproliferative disorder originating in a pluripotent stem cell.
2004
The Hematology category covers resources concerned with blood, blood-forming tissues, bone marrow, plasma, and transfusions. Coverage also includes resources on specialties such as hemophilia, leukemia, and lymphoma.
HAEMATOLOGICA
sì
WOS:000220630600017
2-s2.0-2942724096
Esperti anonimi
Inglese
Internazionale
STAMPA
89
4
497
499
2
15075087
Title: Haematologica ISSN: 0390-6078 (Print) 1592-8721 (Electronic) Title Abbreviation: Haematologica ISO Abbreviation: Haematologica Publication Start Year: 1920 Current Indexing Status: Currently indexed for MEDLINE. Current Subset: Index Medicus Version Currently Indexed: Electronic PMC Availability: See PubMed Central for available issues. Publisher: Ferrata Storti Foundation, Continuation Notes: Absorbed: Hematology journal. 2005 Language: English, Italian Place of Publication: Italy Subject Term(s): Hematology NLM ID: 0417435
MYELOID NEOPLASM; CHRONIC MYELOPROLIFERATIVE DISORDER; HYPEREOSINIPHILIC SYNDROME
http://www.haematologica.org/cgi/reprint/89/4/497
no
6
info:eu-repo/semantics/article
262
Malcovati, Luca; La Starza, R; Merante, S; Pietra, D; Mecucci, C; Cazzola, Mario
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/141971
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