We report a novel approach for the modular and convergent construction of biocompatible graft copolymers starting from bacterial poly(γ-glutamic acid)(γ-PGA) and incorporating poly(lactic acid) (PLA). This synthesis strategy is controlled at different levels: (a) the choice of a suitable initiator for the ring-opening polymerization of lactide; (b) the chemical elaboration of the polylactic fragments; and (c) their convergent "grafting to"functionalization of bacterial γ-PGA propargyl ester using copper(i)-catalyzed alkyne-azide cycloaddition (CuAAC) click chemistry. The graft copolymers are characterized in terms of their thermal and macromolecular properties, their conformational preferences through molecular modelling, and their cytotoxicity.
Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid)
Zaccaria C. L.;Cedrati V.;Nitti A.;Chiesa E.;Colombo G.;Pasini D.
2021-01-01
Abstract
We report a novel approach for the modular and convergent construction of biocompatible graft copolymers starting from bacterial poly(γ-glutamic acid)(γ-PGA) and incorporating poly(lactic acid) (PLA). This synthesis strategy is controlled at different levels: (a) the choice of a suitable initiator for the ring-opening polymerization of lactide; (b) the chemical elaboration of the polylactic fragments; and (c) their convergent "grafting to"functionalization of bacterial γ-PGA propargyl ester using copper(i)-catalyzed alkyne-azide cycloaddition (CuAAC) click chemistry. The graft copolymers are characterized in terms of their thermal and macromolecular properties, their conformational preferences through molecular modelling, and their cytotoxicity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
