In this article, Cattaneo, Buffo, Besusso, and colleagues investigate the short-term in vivo therapeutic benefits of a cell replacement approach for Huntington disease (HD) using hESC-derived MSN progenitors. Upon intra-striatal transplantation in a neurotoxin model of HD, donor cells survive and mature in the host tissue reaching appropriate target regions, establishing synaptic contacts and mitigating lesion-dependent sensorimotor deficits.
Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease
Spaiardi P.;Talpo F.;Toselli M. G.;Biella G.;
2020-01-01
Abstract
In this article, Cattaneo, Buffo, Besusso, and colleagues investigate the short-term in vivo therapeutic benefits of a cell replacement approach for Huntington disease (HD) using hESC-derived MSN progenitors. Upon intra-striatal transplantation in a neurotoxin model of HD, donor cells survive and mature in the host tissue reaching appropriate target regions, establishing synaptic contacts and mitigating lesion-dependent sensorimotor deficits.File in questo prodotto:
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