Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3)−H activation, exploiting chelation assistance by modular triazoles. The C−H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the easy access to novel fluorogenic boron-dipyrrin (BODIPY)-labeled probes for live-cell imaging.
BODIPY-Labeled Cyclobutanes by Secondary C(sp3)−H Arylations for Live-Cell Imaging
Virelli M.;Zanoni G.
;Ackermann L.
2019-01-01
Abstract
Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3)−H activation, exploiting chelation assistance by modular triazoles. The C−H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the easy access to novel fluorogenic boron-dipyrrin (BODIPY)-labeled probes for live-cell imaging.File in questo prodotto:
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