Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3)−H activation, exploiting chelation assistance by modular triazoles. The C−H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the easy access to novel fluorogenic boron-dipyrrin (BODIPY)-labeled probes for live-cell imaging.

BODIPY-Labeled Cyclobutanes by Secondary C(sp3)−H Arylations for Live-Cell Imaging

Virelli M.;Zanoni G.
;
Ackermann L.
2019

Abstract

Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3)−H activation, exploiting chelation assistance by modular triazoles. The C−H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the easy access to novel fluorogenic boron-dipyrrin (BODIPY)-labeled probes for live-cell imaging.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11571/1447224
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