The electrochemical behaviour of two alkaloids of forensic interest, namely glaucine and tetrahydropalmatine, has been investigated by Cyclic Voltammetry (CV) and Controlled Potential Electrolysis (CPE) and the results compared with those obtained with model compounds such as tetrahydroisoquinolines and methoxybenzenes. On the basis of these results, we developed an analytical procedure based on differential pulsed voltammetry (DPV), associated with a clean-up/preconcentration process by solid phase extraction (SPE) using Florisil, that can be applied for the detection and quantification of the analytes both in pharmaceutical preparations and in biological matrices such as urines. LOD values around 0.15 µg∙mL−1 and linearity up to 250 µg∙mL−1 were measured.
Electrochemical analysis and characterization of psychoactive substances glaucine and tetrahydropalmatine
Capucciati A.;Protti S.;Profumo A.;Merli D.
2022-01-01
Abstract
The electrochemical behaviour of two alkaloids of forensic interest, namely glaucine and tetrahydropalmatine, has been investigated by Cyclic Voltammetry (CV) and Controlled Potential Electrolysis (CPE) and the results compared with those obtained with model compounds such as tetrahydroisoquinolines and methoxybenzenes. On the basis of these results, we developed an analytical procedure based on differential pulsed voltammetry (DPV), associated with a clean-up/preconcentration process by solid phase extraction (SPE) using Florisil, that can be applied for the detection and quantification of the analytes both in pharmaceutical preparations and in biological matrices such as urines. LOD values around 0.15 µg∙mL−1 and linearity up to 250 µg∙mL−1 were measured.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
