How much resistance exercise is beneficial for healthy aging and longevity?

Resistance exercise (RE) is an important physical activity modality conferring major health benefits that are partially complementary to benefits from endurance exercise. • Recent meta-analyses reveal a U-shaped relationship between RE volumes and mortality, with optimal benefits achieved at about 60 min of RE per week. • The mechanisms for potential adverse effects at higher RE volumes are unknown and may be due to hitherto undefined confounders and/or specific individual vulnerabilities. • Wearable technologies and advanced data analysis methods provide exciting tools to explore such risk factors. • Presently, there is no convincing reason for healthy individuals to reduce their RE activities.