Our data, collectively, did not reveal any signifcant efect of BNT162b2 on patient and physician perception of disease activity, systemic infammation, and clinical and subclinical synovitis both after induction and booster doses. The observed fare rates are in line with those reported in literature for nonvaccinated patients both in drug-free and under csDMARD treatment. Despite the restriction of the current analysis to a specifc niche of patients limits the generalizability of the conclusions to the entire clinical spectrum of RA, our data indicate that active and repeated immunization per se is insufcient to lead to detectable short-term reactivation of RA natural dynamics in stable quiescent disease.
No evidence of short-term impact of repeated BNT162b2 vaccination on rheumatoid arthritis homeostasis in drug-free remission
Bozzalla Cassione, Emanuele;Mansoubi, Mehrad;Mazzucchelli, Iolanda;Luvaro, Terenzj;De Stefano, Ludovico;Xoxi, Blerina;Grignaschi, Silvia;Bugatti, Serena;Montecucco, Carlomaurizio;Manzo, Antonio
2022-01-01
Abstract
Our data, collectively, did not reveal any signifcant efect of BNT162b2 on patient and physician perception of disease activity, systemic infammation, and clinical and subclinical synovitis both after induction and booster doses. The observed fare rates are in line with those reported in literature for nonvaccinated patients both in drug-free and under csDMARD treatment. Despite the restriction of the current analysis to a specifc niche of patients limits the generalizability of the conclusions to the entire clinical spectrum of RA, our data indicate that active and repeated immunization per se is insufcient to lead to detectable short-term reactivation of RA natural dynamics in stable quiescent disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
