The photochemical metal-free carboamidation of aryl radicals has been exploited for the preparation of aromatic amides, including hetero-and polyaromatic derivatives, under visible light irradiation of arylazo sulfones in the presence of isocyanides in aqueous acetonitrile. The process was useful for the smooth preparation of the antidepressant moclobemide.

A Visible-Light-Driven, Metal-free Route to Aromatic Amides via Radical Arylation of Isonitriles

Marco Malacarne;Stefano Protti;Maurizio Fagnoni
2017-01-01

Abstract

The photochemical metal-free carboamidation of aryl radicals has been exploited for the preparation of aromatic amides, including hetero-and polyaromatic derivatives, under visible light irradiation of arylazo sulfones in the presence of isocyanides in aqueous acetonitrile. The process was useful for the smooth preparation of the antidepressant moclobemide.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1476894
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