In the present work, we describe the electrochemical behaviour of two opioids structurally related to aroyl amides of forensic interest, namely U-47700 and AH-7921. The data obtained allowed for the mise-au-point of a voltammetric determination protocol, that relies on differential pulse voltammetry (DPV) at a glassy carbon electrode in ethanol/0.1 M lithium perchlorate/0.10 M 2,6-lutidine. To apply the method to the analysis of real samples (urines), a clean-up and a preconcentration strategy by solid phase extraction (SPE) using the adsorbent Florisil have been developed. LOQ of 0.2 mu g center dot mL(-1) in urine samples with an enrichment factor of 20 and linear range from 5 to 150 mu g center dot mL(-1) were obtained.

Electrochemical Behavior and Voltammetric Determination of Two Synthetic Aroyl Amides Opioids

Capucciati, A;Protti, S;Profumo, A;Merli, D
2023-01-01

Abstract

In the present work, we describe the electrochemical behaviour of two opioids structurally related to aroyl amides of forensic interest, namely U-47700 and AH-7921. The data obtained allowed for the mise-au-point of a voltammetric determination protocol, that relies on differential pulse voltammetry (DPV) at a glassy carbon electrode in ethanol/0.1 M lithium perchlorate/0.10 M 2,6-lutidine. To apply the method to the analysis of real samples (urines), a clean-up and a preconcentration strategy by solid phase extraction (SPE) using the adsorbent Florisil have been developed. LOQ of 0.2 mu g center dot mL(-1) in urine samples with an enrichment factor of 20 and linear range from 5 to 150 mu g center dot mL(-1) were obtained.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1477445
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