It is well known the deleterious effect of alcohol on the oral health of alcoholics.We investigated the effects of the first metabolite of alcohol, the acetaldehyde, that was demonstrated to be present in a toxic quantity in the human mouth because of an enzymatic imbalance. In this investigation we examined the noxious local effect of alcohol via its first metabolite acetaldehyde on integrin expression in periodontal ligament fibroblasts (PDLFs) “in vitro”.A dose dependent acetaldehyde influence on mRNAs encoding for alpha and beta integrin subunits was detected with both the molecular and the immunocytochemical approach suggesting an altered compartmentalization process in which the integrin molecules are produced but are not appropriately transferred to the cell membrane.
Alcohol-Metabolite Acetaldehyde Affects Integrin Expression on PDLFs
RODRIGUEZ Y BAENA, RUGGERO;RIZZO, SILVANA;POGGI, PAOLA
2004-01-01
Abstract
It is well known the deleterious effect of alcohol on the oral health of alcoholics.We investigated the effects of the first metabolite of alcohol, the acetaldehyde, that was demonstrated to be present in a toxic quantity in the human mouth because of an enzymatic imbalance. In this investigation we examined the noxious local effect of alcohol via its first metabolite acetaldehyde on integrin expression in periodontal ligament fibroblasts (PDLFs) “in vitro”.A dose dependent acetaldehyde influence on mRNAs encoding for alpha and beta integrin subunits was detected with both the molecular and the immunocytochemical approach suggesting an altered compartmentalization process in which the integrin molecules are produced but are not appropriately transferred to the cell membrane.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
