We report two different synthetic approaches for the stereoselective synthesis of (2E,4E)-4-(4,4-dimethylpent- 2-ynylidene)-N1,N5-dimethyl-N1,N5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine 1, an important impurity-reference standard for the chemical characterization of terbinafine. The diamine 1 was obtained in only six steps with a good overall yield starting from commercially available glutaconic acid.
Novel stereoselective syntheses of (2E,4E)-4-(4,4-dimethylpent-2-ynylidene)-N1,N5-dimethyl-N1,N5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine
COLOMBO, LINO
;DI GIACOMO, MARCELLO
;SERRA, MASSIMO;TAMBINI, SIMONE MARIA
2009-01-01
Abstract
We report two different synthetic approaches for the stereoselective synthesis of (2E,4E)-4-(4,4-dimethylpent- 2-ynylidene)-N1,N5-dimethyl-N1,N5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine 1, an important impurity-reference standard for the chemical characterization of terbinafine. The diamine 1 was obtained in only six steps with a good overall yield starting from commercially available glutaconic acid.File in questo prodotto:
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