Background: In patients with cystic fibrosis (CF) there is a direct relationship between nutritional status and lung function. Gastrostomy (GT) allows larger and continuous caloric intake and is an option in cases where the oral route is not sufficient Methods: A multicenter retrospective study of pediatric CF patients who underwent gastrostomy between 2007 and 2021 in 7 referral centers for CF in Brazil. Some variables were collected in a chart review to characterize the sample. Anthropometric data: Z score for weight, height, Body Mass Index (BMI) and lung function (FEV1) were evaluated and compared at 5 different time points: pre-placement of GT (12 and 6 months before), at the time of placement and after procedure (6 and 12 months). Results: 42 patients were included in the study. BMI Z score decreased significantly 6 months before GT from -2.04 ± 1.6 to -2.2 ± 1.4 (p< 0.05), however, after 6 and 12 months of GT there was an increase in this parameter, -1.5 ± 1.4 and -1.5 ±1.6 (p<0.05) respectively. FEV1 showed a sharp drop from 12 months to 6 months before GT from 63% ± 18 to 48% ±19 (P< 0.05). From the time of GT placement there was a stabilization in FEV1 at 6, 12 and 24 months after (50 ±18%, 47 ±19%, 40 ±23% 43 ± 27%). Conclusions: GT placement was a significant improvement in BMI Z score. We observed a marked decline in lung function prior to GT placement with a stabilization at 6 and 12 months after.
Retrospective Study Pre and Post Gastrostomy in Pediatric Patients with Cystic Fibrosis: Brazilian Multicenter Study
Lenycia de Cassya Lopes Neri;
2024-01-01
Abstract
Background: In patients with cystic fibrosis (CF) there is a direct relationship between nutritional status and lung function. Gastrostomy (GT) allows larger and continuous caloric intake and is an option in cases where the oral route is not sufficient Methods: A multicenter retrospective study of pediatric CF patients who underwent gastrostomy between 2007 and 2021 in 7 referral centers for CF in Brazil. Some variables were collected in a chart review to characterize the sample. Anthropometric data: Z score for weight, height, Body Mass Index (BMI) and lung function (FEV1) were evaluated and compared at 5 different time points: pre-placement of GT (12 and 6 months before), at the time of placement and after procedure (6 and 12 months). Results: 42 patients were included in the study. BMI Z score decreased significantly 6 months before GT from -2.04 ± 1.6 to -2.2 ± 1.4 (p< 0.05), however, after 6 and 12 months of GT there was an increase in this parameter, -1.5 ± 1.4 and -1.5 ±1.6 (p<0.05) respectively. FEV1 showed a sharp drop from 12 months to 6 months before GT from 63% ± 18 to 48% ±19 (P< 0.05). From the time of GT placement there was a stabilization in FEV1 at 6, 12 and 24 months after (50 ±18%, 47 ±19%, 40 ±23% 43 ± 27%). Conclusions: GT placement was a significant improvement in BMI Z score. We observed a marked decline in lung function prior to GT placement with a stabilization at 6 and 12 months after.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
