The aim of the study was to assess the efficacy and the tolerability of topical PUVA-treatment in a group of psoriatic patients. Twenty-seven patients affected either by palmoplantar psoriasis (25 patients) or diffuse psoriasis associated with liver disfunction (2 patients) were treated with topical photochemotherapy. The affected sites were bathed in a hydro-alcoholic solution of 3 mg/l of 8-methoxypsoralen (8-MOP) at 37 °C. After bathing, the wet skin area was exposed 3 times a week to gradually increasing energy doses of UVA (the initial UVA dose was of 1-1.5 J/cm2; the increase was of 0.5 J/cm2 each time). Seventeen out of 27 patients (including the 2 patients with diffuse psoriasis) showed a complete remission after an average dose of 384 ± 43 J/cm2. Six patients showed incomplete remission; in 4 patients the therapy was discontinued after 2 months because of a lack of clinical improvement. The average remission period after withdrawal of treatment was shorter than that induced by oral photochemotherapy (50 days vs 75 days). However, the topical approach of photochemotherapy seems to be a useful aid in treating localized forms of psoriasis, or diffuse forms in which oral systemic treatment with psoralens is contraindicated.
Topical photochemotherapy for psoriasis
Brazzelli V.
;
1992-01-01
Abstract
The aim of the study was to assess the efficacy and the tolerability of topical PUVA-treatment in a group of psoriatic patients. Twenty-seven patients affected either by palmoplantar psoriasis (25 patients) or diffuse psoriasis associated with liver disfunction (2 patients) were treated with topical photochemotherapy. The affected sites were bathed in a hydro-alcoholic solution of 3 mg/l of 8-methoxypsoralen (8-MOP) at 37 °C. After bathing, the wet skin area was exposed 3 times a week to gradually increasing energy doses of UVA (the initial UVA dose was of 1-1.5 J/cm2; the increase was of 0.5 J/cm2 each time). Seventeen out of 27 patients (including the 2 patients with diffuse psoriasis) showed a complete remission after an average dose of 384 ± 43 J/cm2. Six patients showed incomplete remission; in 4 patients the therapy was discontinued after 2 months because of a lack of clinical improvement. The average remission period after withdrawal of treatment was shorter than that induced by oral photochemotherapy (50 days vs 75 days). However, the topical approach of photochemotherapy seems to be a useful aid in treating localized forms of psoriasis, or diffuse forms in which oral systemic treatment with psoralens is contraindicated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
