We present a novel and highly efficient method for synthesizing polyfunctionalized 1,2,4-triazoles. This approach leverages visible light and arylazo sulfones in combination with N-vinyl amides, in the environmentally friendly solvent ethyl acetate. Remarkably, the reaction proceeds without the need for (photo)catalysts, ensuring near-perfect atom economy and producing only water as a by-product. This method exhibits excellent functional group tolerance and can be scaled for both batch and continuous-flow processes.
Visible-Light Enabled Synthesis of 1-Aryl-3-Sulfonylmethyl-1,2,4-Triazoles by Arylazo Sulfones.
Nicchio L.;Di Terlizzi L.;Fagnoni M.;Protti S.;
2025-01-01
Abstract
We present a novel and highly efficient method for synthesizing polyfunctionalized 1,2,4-triazoles. This approach leverages visible light and arylazo sulfones in combination with N-vinyl amides, in the environmentally friendly solvent ethyl acetate. Remarkably, the reaction proceeds without the need for (photo)catalysts, ensuring near-perfect atom economy and producing only water as a by-product. This method exhibits excellent functional group tolerance and can be scaled for both batch and continuous-flow processes.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
