Juvenile Mycosis Fungoides: A Multicenter Retrospective Italian Study

Why Was the Study Undertaken? ∘ The study aimed to characterise juvenile‐onset mycosis fungoides (JMF), a rare and under‐ recognised cutaneous T‐cell lymphoma. The researchers analysed the clinical, histopathological, and immunophenotypic features; treatment response; and long‐term outcomes of a multicenter Italian cohort. They paid particular attention to age‐ related differences. • What Does This Study Add? ∘ It is one of the largest Southern European JMF cohorts with extended follow‐up. The study confirms the high prevalence of CD8⁺ phenotypes and hypopigmented variants, highlights a frequent association of JMF with atopic dermatitis in younger children, and identifies a possible age‐related gradient in long‐term remission rates. • What Are the Implications of This Study for Understanding the Disease and/or Providing Clinical Care? ∘ The findings support recognising JMF as a clinically and biologically distinct entity. Earlier onset of the disease may predict more sustained remission, which underscores the need for paediatric‐specific diagnostic vigilance and management guidelines