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Schistosoma infections remain a major public health issue mainly in tropical and subtropical regions. While Praziquantel is the primary treatment for schistosomiasis, its limitations include resistance development and poor efficacy against juvenile worms. Given the biological similarities between tumor and parasite-infected cells, LSD1 inhibitors─primarily explored as anticancer agents─have been investigated for their antiparasitic potential.

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni

Caroli, Jonatan
Methodology
;Mattevi, Andrea
Methodology
;Mai, Antonello
Supervision
2025-01-01

Abstract

Schistosoma infections remain a major public health issue mainly in tropical and subtropical regions. While Praziquantel is the primary treatment for schistosomiasis, its limitations include resistance development and poor efficacy against juvenile worms. Given the biological similarities between tumor and parasite-infected cells, LSD1 inhibitors─primarily explored as anticancer agents─have been investigated for their antiparasitic potential.
2025
Biochemistry & Biophysics focuses on the structure and chemistry of biomolecules and covers all aspects of basic biochemistry/biophysics, including molecular structure, enzyme kinetics and protein-protein interaction; this category also contains cross-disciplinary resources focused on a specific class of biological molecules, e.g., nucleic acids, steroids, magnesium, growth factors, free radicals, bio-membranes, and peptides. Excluded are resources dealing with the application of biochemical techniques to specific topics listed elsewhere in CC/LS. Resources with a strong emphasis on the integration of biochemical pathways (such as signal transduction or molecular motors) at the cellular level are placed in the Cell & Developmental Biology category.
ACS INFECTIOUS DISEASES
sì
WOS:001521735200001
2-s2.0-105009607477
Esperti anonimi
Inglese
Internazionale
ELETTRONICO
11
8
2178
2189
12
40601861
LSD1; S. mansoni; cytotoxicity; lysine demethylases; reduction of viability
https://pubs.acs.org/doi/10.1021/acsinfecdis.5c00224
sì
16
info:eu-repo/semantics/article
262
Fabbrizi, Emanuele; Hailu, Gebremedhin Solomon; Ganesan, A; Fioravanti, Rossella; Zwergel, Clemens; Lambona, Chiara; Valente, Sergio; Fianco, Giulia; ...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1546776
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