Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.

Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host

SPEZIALE, PIETRO;PIETROCOLA, GIAMPIERO;RINDI, SIMONETTA;PROVENZANO, MARIA;DI POTO, ANTONELLA;VISAI, LIVIA;
2009-01-01

Abstract

Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/203855
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