DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of muco- sal DCs have been described that display unique functions, dictated in part by the local microen- vironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflam- matory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.
Dendritic cells in intestinal homeostasis and disease.
DI SABATINO, ANTONIO
2009-01-01
Abstract
DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of muco- sal DCs have been described that display unique functions, dictated in part by the local microen- vironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflam- matory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
