Potassium channels are key players in the control of cardiac action potential, and their dysfunction can lead to atrial and ventricular arrhythmias. Mutations in genes encoding voltage-gated potassium channels, leading to their loss of function, cause long QT syndrome and Andersen-Tawil syndrome. Mutations in potassium-channel genes, leading to their gain of function, cause short QT syndrome and familial atrial fibrillation. Recently, the potassium-channel KATP has been implicated in early repolarization syndrome and in Brugada syndrome.
Inherited cardiac arrhythmia syndrome. Role of potassium channels
CROTTI, LIA;INSOLIA, ROBERTO;SCHWARTZ, PETER
2011-01-01
Abstract
Potassium channels are key players in the control of cardiac action potential, and their dysfunction can lead to atrial and ventricular arrhythmias. Mutations in genes encoding voltage-gated potassium channels, leading to their loss of function, cause long QT syndrome and Andersen-Tawil syndrome. Mutations in potassium-channel genes, leading to their gain of function, cause short QT syndrome and familial atrial fibrillation. Recently, the potassium-channel KATP has been implicated in early repolarization syndrome and in Brugada syndrome.File in questo prodotto:
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