Screening of Fibrillogenesis Inhibitors of β2-microglobulin: Integrated Strategies by Mass Spectrometry, Capillary Electrophoresis and in Silico Simulations

Innovative integrated strategy involving analytical methods (mass spectrometry and capillary electrophoresis) and in silico approaches (QSAR, virtual screening) to identify beta2-microglobulin binders also endowed with anti amyloid activity; study of structure-activity relationships. Integrazione innovativa tra metodi analitici (spettrometria di massa e elettroforesi capillare) e in silico (QSAR, virtual screening) per individuare molecole affini alla proteina amiloidogenica beta2-microglobulina e dotate di attività biologica (anti-amiloide); studio delle relazioni tra struttura chimica e attività biologica.