Appetite Control and Glycaemia reduction in Overweight Subjects treated with a Combination of Two Highly Standardized Extracts from Phaseolus vulgaris and Cynara scolymus

The management of overweight may include the use of dietary supplements targeted to favor the increase of the satiation associated with decrease in blood glucose and lipid levels. The aim of this study is to evaluate the efficacy of a dietary supplementation with an extract from Phaseolus vulgaris and Cynara scolymus, on the satiation, the glucose and lipid pattern. A randomized, double-blind, placebo-controlled clinical trial was performed in 39 overweight subjects (20 supplemented group, 19 placebo group) for 2 months. The modification of satiation, by Haber’s scale, was the primary end-point, and the variation of the glucose and lipid pattern, of the anthropometric parameters and of the psychodynamic tests score were the secondary end-points. At the end of treatment, the net change of the Haber’s mean score significantly increased in the intervention group. The net change of the glycemia and of the dietary restriction score of Three Factor Eating Questionnaire (TFEQ), were significantly reduced just in the intervention group. Moreover, in the supplemented group, the Homeostasis Model Assessment, the Body Mass Index and the susceptibility-to-hunger score of the TFEQ, decreased significantly after intervention; these parameters did not change in the controls. This treatment appears potentially useful in the management of overweight and dysglycemia.