A straightforward route for the preparation of 6-substituted naphthols and 6,6'-disubstituted binols (binol=2,2'-dihydroxy-1,1'-binaphthyl) is presented. The synthesis has been accomplished by a one-step procedure starting from 6-bromo derivatives via direct lithiation with n-BuLi, followed by the addition of several electrophiles.
Protecting Group Free Synthesis of 6-Substituted Naphthols and Binols
VERGA, DANIELA;PERCIVALLE, CLAUDIA;DORIA, FILIPPO;PORTA, ALESSIO;FRECCERO, MAURO
2011-01-01
Abstract
A straightforward route for the preparation of 6-substituted naphthols and 6,6'-disubstituted binols (binol=2,2'-dihydroxy-1,1'-binaphthyl) is presented. The synthesis has been accomplished by a one-step procedure starting from 6-bromo derivatives via direct lithiation with n-BuLi, followed by the addition of several electrophiles.File in questo prodotto:
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