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Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C.

Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C.

BRUNO, RAFFAELE;
2011-01-01

Abstract

Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C.
2011
Medical Research, General Topics covers a wide array of topics in medical and biomedical research, with a specific emphasis on human disease, human tissues, and all levels of research into the pathogenesis of clinically significant conditions. Specific medical fields that are characterized by the inclusion of material from several other specializations are also covered here; these include general and internal medicine, tropical medicine, pediatrics, gerontology, epidemiology, and public health. Resources dealing with specific clinical interventions are excluded and are placed in the Medical Research: Diagnosis & Treatment category. Resources that emphasize the specific disease types, or specific systems affected are also excluded and are categorized according to the pathogen or system pathophysiology.
THE JOURNAL OF INFECTIOUS DISEASES
000287028000005
2-s2.0-79751511058
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
203
595
601
6
21257738
Adult; Aged; 80 and over; CD4 Lymphocyte Count; Case-Control Studies; Female; Genotype; HIV Infections; complications/diagnosis/genetics; Hepacivirus; genetics; Hepatitis C; genetics/virology; Humans; Interleukins; Male; Middle Aged; Polymorphism; Single Nucleotide; RNA; Viral; analysis; Regression Analysis; Treatment Outcome
http://dx.doi.org/10.1093/infdis/jiq098
21
info:eu-repo/semantics/article
262
Jacob, Nattermann; Martin, Vogel; Hans Dieter, Nischalke; Mark, Danta; Stefan, Mauss; Hans Jörg, Stellbrink; Axel, Baumgarten; Christoph, Mayr; Bruno,...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/256704
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